On his uncle's death Sir Henry Baskerville returns from abroad and opens up the ancestral hall on the desolate moors of Devonshire. Holmes uncovers a plot to have Sir Henry murdered by a terrible trained hound. First casting of Rathbone and Bruce as Holmes and Watson.

Professor Moriarity has a scheme for stealing the crown jewels from the Tower of London. To get Holmes involved, he persuades a gaucho flute player to murder a girl.

Dr. Frankenstein and his monster both turn out to be alive, not killed as previously believed. Dr. Frankenstein wants to get out of the evil experiment business, but when a mad scientist, Dr. Pretorius, kidnaps his wife, Dr. Frankenstein agrees to help him create a new creature, a woman, to be the companion of the monster. Written by John Oswalt